Can adjust powder characteristics:
Since many of today's therapeutic compounds are only stable in a cystalline form, they often display poor aqueous solubilitiy and low dissolution rates, thus reducing the bioavailability of the API and slowing absorption. The spray drying process can co-precipitate an API with a polymer in a stable amorphous solid dispersion (SDD) resulting in greatly improved dissolution rates. Spray drying has the potential to open doors for new, important treatments that are currently shelved due to low bioavailability.
Microencapsulation offers formulators a number of commercial advantages. Spray drying/congealing makes it possible to create unique particles possessing specific controlled release patterns and properties. Sustained release of some antibiotics allows for a reduction in dosage, a reduction of concentration peaks and offers an effective way of treatment for chronic illnesses. Microencapsulation is also utilized for enhanced taste masking, moisture barries, and product stability thru physical protection.
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